Janne Nikkilä, Christophe Roos, and Samuel Kaski Exploring Dependencies between Yeast Stress Genes and their Regulators In proceedings of International conference on intelligent data engineering and automated learning 2004, Exeter, UK, August 25-27, 2004. ( postscript, gzipped postscript)

An environmental stress response gene should, by definition, have common properties in its behavior across different stress treatments. We search for such common properties by models that maximize common variation, and explore potential regulators of the stress response by further maximizing mutual information with transcription factor binding data. A computationally tractable combination of generalized canonical correlations and clustering that searches for dependencies is proposed and shown to find promising sets of genes and their potential regulators.

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Last modified: Wed Mar 9 08:35:04 EET 2005